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pentobarbital will lower the level or result of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Lack of, or lessened reaction to tofacitinib may arise when coadministered with potent CYP3A4 inducerspentobarbital will minimize the extent or effect of vinorelbine by affecting hepatic/intestinal enzyme